Feasibility of Cardiac Exercise Rehabilitation in Patients with Cardiac Amyloidosis

Authors

  • Thibaud Damy APHP, CHU Henri Mondor, Créteil
  • Barnabas Gellen ELSAN, Polyclinique de Poitiers, France
  • Silvia Oghina APHP, Mondor University Hospital Group, Department of Cardiology and Cardiac Rehabilitation, Creteil, France
  • Mijiti Wuliya APHP, Mondor University Hospital Group, Department of Cardiology and Cardiac Rehabilitation, Creteil, France
  • Habib Ben Eljah APHP, Mondor University Hospital Group, Department of Cardiology and Cardiac Rehabilitation, Creteil, France
  • Soulef Guendouz APHP, Mondor University Hospital Group, Department of Cardiology and Cardiac Rehabilitation, Creteil
  • Sandrine Peyrot ELSAN, Polyclinique de Poitiers, France
  • Pierre Vladimir Ennezat APHP, Mondor University Hospital Group, Department of Cardiology and Cardiac Rehabilitation, Creteil, France
  • Luc Hittinger APHP, Mondor University Hospital Group, Department of Cardiology and Cardiac Rehabilitation, Creteil, France
  • Emmanuel Teiger APHP, Mondor University Hospital Group, Department of Cardiology and Cardiac Rehabilitation, Creteil, France
  • Laura Ernande APHP, Mondor University Hospital Group, Department of Cardiology and Cardiac Rehabilitation, Creteil, France
  • Florence Canoui-Poitrine APHP, Henri-Mondor hospital, Public Health Department and Clinical Research Unit (URC-Mondor), Creteil, France

DOI:

https://doi.org/10.52057/erj.v3i1.27

Keywords:

AL amyloidosis, amyloidosis, ATTRv amyloidosis, ATTRwt amyloidosis, cardiac exercise rehabilitation

Abstract

Objective: We aimed to determine if cardiac exercise rehabilitation was feasible and beneficial in patients with cardiac amyloidosis.

Methods: This prospective single-centre pilot study was proposed to all adult patients, diagnosed with cardiac amyloidosis, and referred to the cardiac rehabilitation centre at the Henri Mondor University hospital (Créteil, France) between 2011 to 2015. All patients had clinical evaluations, laboratory tests, and echocardiographic examinations when presenting at the hospital. The cardiac exercise rehabilitation programme, in this study, comprised a baseline incremental system-limited exercise test followed by 20 endurance training sessions at a constant workload. Cardiac exercise rehabilitation was feasible if the patient completed the baseline test and ≥10 sessions without an exercise limiting adverse event. Patients with a relative increase of ≥16% in in VO2 max and/or maximal workload were considered to have benefited from cardiac exercise rehabilitation.

Results: Overall, 27 cardiac amyloidosis patients were recruited. Cardiac exercise rehabilitation was feasible in 19 (70%) and not feasible in 8 (30%). Of the 19 patients where cardiac exercise rehabilitation was feasible, cardiac exercise rehabilitation benefited 9 (47%). This benefit was significantly associated with lower N-type pro-brain natriuretic peptide levels, lower creatinineamia, and higher left ventricular ejection fraction at baseline.

Conclusion: Cardiac exercise rehabilitation is feasible and beneficial in selected patients with cardiac amyloidosis.

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Published

2023-06-26

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Original Research

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